Angel Medina started his career at Megaton comics, where he worked on the titles Beserker and Megaton. Shortly after he began working at First Publishing where he had work on the titles Dreadstar and Hammer of God. He began working for Marvel Comics in the late 1980's where he worked on The Incredible Hulk, Warlock and the Infinity Watch, Blackwulf, Avengers, The Amazing Spider-Man, Marvel Knights Spider-Man and Venom: Dark Origin. After this he began doing work for Image comics, where he had work published on Sam and Twitch, and then the main spawn series. He is very well known for his work on KISS: Psycho Circus